مهندسی شیمی ایران

مهندسی شیمی ایران

کاربرد و اهمیت هیدروژل‌های حساس به pH در دارورسانی

نوع مقاله : مقاله مروری

نویسندگان
1 دانشجوی دکتری مهندسی شیمی، دانشگاه صنعتی سهند
2 دانشیار مهندسی شیمی، دانشگاه صنعتی سهند
چکیده
هیدروژل‌ها، شبکه‌های سهبعدی نامحلول در آب هستند که توانایی جذب بسیار زیاد آب را در محیط بیولوژیکی دارند. از مهم‌ترین خصوصیات هیدروژلها، پاسخ برگشت‌پذیر آن‌ها به محرک‌های مختلف ازجمله pH است که باعث کاربرد و اهمیت هیدروژل درزمینه‌های مختلف پزشکی مانند لنزهای تماسی، مهندسی بافت، رهایش عوامل درمانی و زخمپوش‌ها و غیره می‌شود. امروزه بهبود نسبت اثربخشی و ایمنی داروهای موجود بهجای توسعۀ داروهای جدید که مستلزم هزینه و زمان زیادی است، یک چالش مهم است. اثربخشی داروها تحت تأثیر تعدادی از عوامل مانند حلالیت کم آن‌ها در آب، خطر تخریب در محیط اسیدی، جذب نابرابر، نفوذ کم داروها، اثرات جانبی سیستماتیک و غیره است و باتوجهبه بررسی‌های انجامشده، استفادهاز هیدروژل‌های هوشمند، در بهبود اثربخشی دارو نتیجه‌بخش ‌بودهاست. بنابراین هدف از این مطالعه، بررسی نقش هیدروژل‌های حساس به pH در دارورسانی، سازوکار، تورم و انتشار دارو به‌وسیلۀ این هیدروژلها است.
کلیدواژه‌ها

موضوعات


عنوان مقاله English

Application and Importance of pH Sensitive Hydrogels in Drug Delivery

نویسندگان English

L. Nedaei 1
H. Shokrkar 2
1 Ph. D. Student of Chemical Engineering, Sahand University of Technology
2 Ph. D. Student of Chemical Engineering, Sahand University of Technology
چکیده English

Hydrogels are water-insoluble three-dimensional networks that have the ability to absorb a lot of water in the biological environment. One of the most important characteristics of hydrogels is their reversible response to various stimuli, including pH, which causes the application and importance of hydrogel in various medical fields, such as contact lenses, tissue engineering, release of therapeutic agents, wound dressings, etc. Today, improving the effectiveness and safety ratio of existing drugs is an important challenge instead of developing new drugs that require a lot of money and time. The effectiveness of drugs is affected by a number of factors such as their low solubility in water, the risk of destruction in acidic environments, uneven absorption, low penetration of drugs, systematic side effects, etc. The drug has been effective. Therefore, the aim of this study is to investigate the role of pH-sensitive hydrogels in drug delivery, mechanism, swelling and drug release by these hydrogels.

کلیدواژه‌ها English

pH-Sensitive Hydrogels
Drug Delivery
Drug Release Mechanism
Swelling
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