بسپارهای پرکاربرد در هیدروژل‌های ترمیم‌کنندۀ زخم‌های پوستی- بخش اول

نوع مقاله : مقاله مروری

نویسنده

استادیار مهندسی شیمی، دانشگاه زنجان

چکیده

پوست یکی از بزرگترین اندام‌های بدن انسان است که از آسیب‌های فیزیکی، شیمیایی و میکروبی محیط بیرونی محافظت می‌کند. این اندام پیچیده، قابلیت نوسازی و امکان خودترمیمی دارد؛ اما زخم‌های شدید پوستی، خودبه‌خود در کوتاه‌مدت بهبود نمی‌یابد و نیاز به استفاده از داربست‌های مهندسیشده‌ دارد. در سال‌های اخیر، مهندسی بافت در تولید این ساختارهای ترمیمکنندۀ پوست، پیشرفت‌های چشم‌گیری داشته است. هیدروژل‌ها یکی از مهمترین و کاربردیترین داربست‌های بهبوددهنده و ترمیمکنندۀ پوست به شمار می‌روند. هیدروژل‌ها بر اساس مواد به‌کاررفته در ساختمان خود، به دو دستۀ طبیعی و سنتزی تقسیم می‌شوند. برای عمل‌کرد بهتر و سرعتبخشی به کارکرد هیدروژل‌ها در روند بهبودی زخم، ترکیبی از بسپارهای طبیعی و سنتزی استفاده می‌شود. هدف از ارائۀ این مقالۀ مروری، تمرکز بر ارائۀ اطلاعاتی در مورد انواع بسپارهای کاربردی در ساخت هیدروژل‌های کاربردی بهبوددهندۀ زخم است.

موضوعات


عنوان مقاله [English]

The Most Frequently Used Polymers in Skin Wound Healing Hydrogels-Part One

نویسنده [English]

  • M. Yaghoobi
Assistant Professor of Chemical Engineering, University of Zanjan
چکیده [English]

The skin is one of the largest organs of the human body that protects against physical, chemical and microbial damage of the external environment. This complex organ has the ability to regenerate and has the possibility of self-healing. However, severe skin wounds do not heal on their own in a short period of time and require the use of engineered scaffolds. In recent years, tissue engineering has made tremendous advances in the production of these skin repair structures. Among these structures, hydrogels are one of the most important and practical scaffolds for improving and repairing the skin. Based on the materials used in the construction of hydrogels, hydrogels are divided into two categories: natural and synthetic. A combination of natural and synthetic polymers is used to improve performance and accelerate the function of hydrogels in the wound healing process. The purpose of this review article is to focus on providing information on the types of polymers used to make functional wound healing hydrogels.

کلیدواژه‌ها [English]

  • Hydrogel
  • Wound Healing
  • Synthetic Polymers
  • Natural Polymers
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