همنهشت نانوحامل‌های مزومتخلخل سیلیکا با زیست‌سازگاری بالا و توزیع منظم و یکنواخت حفره‌ها برای دارورسانی داروی دوکسوروبیسین

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشگاه صنعتی سهند- دانشکده مهندسی شیمی

2 دانشکده مهندسی شیمی، دانشگاه صنعتی سهند، تبریز، ایران

3 دانشگاه علوم پزشکی تبریز- دانشکده داروسازی و علوم نوین پزشکی

4 دانشگاه تبریز- دانشکده علوم طبیعی

5 دانشگاه تبریز- دانشکده دامپزشکی

چکیده

در این مطالعه، نانوحامل­های مزومتخلخل سیلیکای زیست‌سازگار همراه با توزیع منظم و یکنواخت حفره‌ها از منابع طبیعی هم‌چون سبوس برنج و گندم تحت فرایند سل- ژل برای دارورسانی پایدار به سلول­های سرطان سینه همنهشت شدند. خواص فیزیکی و شیمیایی نانوحامل­ها با تجزیه‌های  XRD،FT-IR، SEM و BET بررسی شد. نانوحامل‌های حاصل از سبوس برنج و گندم به‌ترتیب دارای مساحت سطح ویژۀ 741 و m2/g 630 همراه با توزیع منظم و یکنواخت حفره‌ها با اندازۀ 6/2 و nm 6/3 بودند. داروی دوکسوروبیسین به‌عنوان داروی مدل در نانوحامل‌ها بارگیری و رهش دارو در دو pH 4/7 و 4/5 بررسی شد. نتایج حاکی از دو برابر شدن نرخ رهش دارو در شرایط اسیدی شبیه­ساز محیط توموری بود.
با بررسی سمیت سلولی نانوحامل­ها روی رده­های سلولی HFF-2 و MCF-7، مشخص شد که نانوحامل­ها دارای زیست‌سازگاری بالا هستند و موجب جلوگیری از رشد و هم‌چنین مرگ سلول‌های سرطانی شده‌اند.

کلیدواژه‌ها


عنوان مقاله [English]

Synthesis of High Biocompatible Mesoporous Silica Nanocarriers with Regular and Uniform Pore Distribution for Doxorubicin Drug Delivery

چکیده [English]

In this study, biocompatible mesoporous silica nanocarriers were synthesized with the regular and uniform pore distribution from natural sources of rice and wheat husk under sol-gel process for sustainable drug delivery to breast cancer cells. The physicochemical properties of nanocarriers were investigated by XRD, FT-IR, SEM and BET analyzes. Nanocarriers obtained from rice and wheat husk had a specific surface area of 741.44 and 630.52 m2/g, respectively, with regular and uniform pore distribution with a size of 2.58 and 3.63 nm. Doxorubicin was loaded as a model drug into the nanocarriers and drug release was evaluated at pH 7.4 and 5.4. The results showed that the drug release rate doubled under acidic conditions which simulating the tumor environment. By examining the cytotoxicity of nanocarriers on the HFF-2 and MCF-7 cell lines, it was found that the nanocarriers have high biocompatibility and prevent the growth and cause to cancerous cells death.

کلیدواژه‌ها [English]

  • Mesoporous Silica Nanoparticles
  • Regular Pore Distribution
  • Rice husk
  • Wheat Husk
  • Drug Delivery
  • breast cancer
 
 
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