The aim of this research is to investigate the interaction of nanoparticles and impurities in amine solutions and natural gas in foam formation, as well as their impact on antifoaming performance in the absorption process of acidic gases (CO2/H2S) from natural gas mixtures. The foaming effect of gases such as carbon dioxide, hydrogen sulfide, methane, ethane, and nitrogen on amine solutions was examined. Subsequently, the effect of four nanoparticles, including nano-alumina, nano-silica, graphene oxide nanoparticles, and multi-walled carbon nanotubes, on the foaming properties of the solvent, as well as the interaction of organic impurities (acetic acid, formic acid, valeric acid, and octanoic acid) and nanoparticles on the solvent's foaming behavior, were analyzed. The results showed that the dissolution of acidic gases in amine solutions leads to an increase in foam formation. Moreover, the presence of nanoparticles increases the foamability of the solvent. Among the nanoparticles, carbon nanotubes exhibited the lowest foam formation in the presence of impurities in amine solutions. Simultaneous presence of nanoparticles and organic pollutants in the solvent resulted in an increase in foam formation by 46% to 260%. Additionally, in the presence of silicone-based antifoam agents, nanoparticles reduced the defoaming rate of the amine solution by up to 100%. The defoaming efficiency was observed in the order of multi-walled carbon nanotubes < graphene oxide < nano-alumina < nano-silica.