Access to safe and clean water remains a major global challenge, with a significant portion of the world's population lacking sufficient sources of safe and sanitary water. This study aims to investigate the use of solar desalination as a sustainable and cost-effective method for treating available unsafe water in remote and sparsely populated area for providing safe drinking water. However, due to the lack of sustainable energy sources and the remoteness of such areas, these highly polluted and unhealthy water sources are unfortunately used for drinking purposes without any purification process. In this study, an inclined basin-type solar desalination system with three installation angles (10°, 20°, and 30°) was employed to purify unhealthy water. Furthermore, the efficiency of solar desalination in reducing or eliminating microbial contamination, a largely underexplored aspect, was specifically examined. The results of the analyses showed that the produced freshwater was completely free of microbial contamination and therefore safe for drinking. The highest yield was observed at a 20° angle, with a production rate of 2750 mL/m²/day.