نوع مقاله : مقاله پژوهشی
نویسندگان
1 گروه بایومتریال، پژوهشکده علوم، پژوهشگاه پلیمر و پتروشیمی ایران
2 پژوهشگاه پلیمر و پتروشیمی ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
In this research, the release kinetics of atorvastatin, which is a hydrophobic drug, from the drug-intercalated layered double hydroxide (LDH) nanoparticles is investigated. For this purpose, LDH nanoparticles were synthesized by co-precipitation method, using two mixing methods (magnetic stirrer and homogenizer) then, atorvastatin was loaded between the layers of LDH nanoparticles. Synthetic LDH particles were characterized by FTIR, XRD, and SEM tests. The SEM test showed that, with the increase in the mixing speed in the synthesis, the size of the particles decreased significantly. The XRD test also determined that the crystallinity decreases as the particle size decreases, which is due to the existence of more violations in the structure of smaller particles. The d-spacing distance between the layers for LDH particles was 7.8 angstroms before drug loading and increased to 33.3 angstroms after drug loading. Visible ultraviolet spectroscopy was used to calculate the amount of loaded drug and obtain the drug release pattern. The obtained results showed that the amount of intercalated drug between layers of synthesized LDH particles with the help of a homogenizer is about 1.8 times more than the amount of drug loaded in LDH particles synthesized through a magnetic stirrer. Drug release was also studied with four kinetic models of penetration-dissolution of zero order, first order, Rigter-Peppas, and Higuchi. The study of the release kinetics of atorvastatin drug from different samples showed that the Higuchi model has the highest and the zero degree model has the lowest agreement with the experimental results.
کلیدواژهها [English]
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