Study of kinetics of drug release from atorvastatin-loaded Layered double hydroxide

Articles in Press

Document Type : Original Article

Authors

1 Department of Biomaterials, Faculty of Sciences, Iran Polymer and Petrochemical Institute

2 Department of Biomaterials, Faculty of Sciences, Iran Polymer and Petrochemical Institute, P.O. Box 14975-112, Tehran, Iran

3 Iran Polymer and Petrochemical Institute, P.O. Box 14975-112, Tehran, Iran

10.22034/ijche.2024.412406.1344

Abstract

In this research, the release kinetics of atorvastatin, which is a hydrophobic drug, from the drug-intercalated layered double hydroxide (LDH) nanoparticles is investigated. For this purpose, LDH nanoparticles were synthesized by co-precipitation method, using two mixing methods (magnetic stirrer and homogenizer) then, atorvastatin was loaded between the layers of LDH nanoparticles. Synthetic LDH particles were characterized by FTIR, XRD, and SEM tests. The SEM test showed that, with the increase in the mixing speed in the synthesis, the size of the particles decreased significantly. The XRD test also determined that the crystallinity decreases as the particle size decreases, which is due to the existence of more violations in the structure of smaller particles. The d-spacing distance between the layers for LDH particles was 7.8 angstroms before drug loading and increased to 33.3 angstroms after drug loading. Visible ultraviolet spectroscopy was used to calculate the amount of loaded drug and obtain the drug release pattern. The obtained results showed that the amount of intercalated drug between layers of synthesized LDH particles with the help of a homogenizer is about 1.8 times more than the amount of drug loaded in LDH particles synthesized through a magnetic stirrer. Drug release was also studied with four kinetic models of penetration-dissolution of zero order, first order, Rigter-Peppas, and Higuchi. The study of the release kinetics of atorvastatin drug from different samples showed that the Higuchi model has the highest and the zero degree model has the lowest agreement with the experimental results.

Keywords

Main Subjects

Iranian Chemical Engineering Journal

Articles in Press, Accepted Manuscript
Available Online from 14 January 2024

Files

Share

How to cite

Statistics