Iranian Chemical Engineering Journal

Iranian Chemical Engineering Journal

Thermodynamic Optimization of Cooling Crystallization of Pharmaceutical and Non‑Pharmaceutical Compounds for Finding the Optimum Solvent

Document Type : Original Article

Author
Assistant Professor of Chemical Engineering, Hamedan University of Technology
Abstract
In the pharmaceutical industry, solvents account for approximately 80-90% of total material consumption. Selecting the optimum solvent and its binary or ternary mixtures in laboratory experiments requires considerable time and cost. Therefore, the use of semi‑predictive thermodynamic models can overcome these limitations. In this study, the UNIQUAC‑SAC activity‑coefficient model, which is a segment‑based thermodynamic model, was employed to model the solubility of 123 solid pharmaceutical and non‑pharmaceutical compounds. First, using reported experimental solubility data, the contribution of conceptual segments for each compound was determined through optimization. These segments were then used to identify the solvent that provides the highest solubility. The obtained results show that the UNIQUAC‑SAC model is a practical thermodynamic model that can be effectively used in the conceptual design stage of pharmaceutical processes for selecting the optimum solvent.
Keywords
Subjects

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