Iranian Chemical Engineering Journal

Iranian Chemical Engineering Journal

Investigation of the Controlled Release Behavior of Amoxicillin from Dextran Hydrogels

Document Type : Original Article

Authors
H. R. Ghafouri Taleghani 1
H. Salimi kenari 1
M. Cheraghi 2
1 Associate Professor of Chemical Engineering, University of Mazandaran
2 M. Sc. Student of Chemical Engineering, University of Mazandaran
10.22034/ijche.2023.401459.1320
Abstract
Dextran is a biodegradable polymer used in medical applications such as wound dressings, artificial skin, and drug delivery carriers. In this study, dextran-based biodegradable hydrogels were prepared through crosslinking reactions using Epichlorohydrin as the crosslinking agent and were used as a drug delivery system for amoxicillin. The prepared hydrogel structure was investigated using Fourier transform infrared spectroscopy. The swelling behavior of the hydrogels was studied in both deionized water and simulated gastric (pH=2) and intestinal (pH=7.4) environments. The results showed that the maximum swelling of the hydrogel after 8 hours was 858%. Fick and Schott models were used to study the swelling kinetics of the hydrogels. Furthermore, the effect of crosslinking agent concentration and temperature on the swelling behavior of the hydrogel was also studied. Moreover, amoxicillin drug was loaded into the hydrogels, and its release from the hydrogels was evaluated in a phosphate buffer solution. The drug release from different samples was studied for a period of 72 hours, and the obtained data were fitted with various kinetic models. The results showed that the hydrogel prepared with 18% Epichlorohydrin and 10% amoxicillin loading was
a suitable candidate for a drug delivery system.
Keywords
Dextran
Drug Release
Hydrogel
Biodegradable
Amoxicillin
Subjects
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Iranian Chemical Engineering Journal
Volume 23, Issue 135
September and October 2024
Pages 46-58